Applications of MyTREC   Assay Kit 
 
TREC (T-Cell Receptor Excision Circle) is a specific marker of T cells of thymic origin and thymic function can be determined by quantitative analysis of TRECs. The MyTREC    Assay Kit specifically measures "Signal Joint TRECs (sjTRECs)" using quantitative Real-Time PCR. The sjTRECs have been shown to most accurately represent thymic output.
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Quantitative TREC analysis has a demonstrated clinical validity in:
  • Detection of Severe Combined Immunodeficiency (SCID) in newborns. SCID is the most severe and fatal variant of Primary     Immunodeficiency diseases
  • Determination of thymic output / immune reconstitution following: Hematopoietic Stem Cell Transplantation (HSCT), Antiretroviral therapy.
  • Assessing T-Cell recovery following thymus transplants as in DiGeorge Syndrome.
  • Evaluating immune competence in patients with primary immunodeficiencies, idiopathic T-Cell deficiencies.
  • Assessing thymic function in patients following chemotherapy, immunosupression, immunotherapy, cancer vaccines.
  • Assessment of naive T-Cell compartment or Recent Thymic Emigrants (RTE) in various immunological contexts.
  • Detection of T-Cell Lymphopenia.
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